You know how Sherlock fans are getting upset over Elementary since Watson is played by Lucy Liu? Baker Street was a comic retelling of Sherlock Holmes published in the late 80s. However, the Sherlock and Watson characters are both women (Sharon and Susan). Sharon is a punk ex-police detective who’s also queer (her girlfriend is a major character) and Susan is an American med student. They live on 112 Baker Street instead of 221 Baker Street, and it takes place in an alternate steampunk 1980s England instead of straight-up Victorian.
And you know what? It’s awesome.
The classics are reinterpreted all the time. Baker Street departed radically from the source material, but Sharon and Susan are still recognizable as Holmes and Watson and are awesome in their own right.